Soy Isoflavones
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Solving the Secret of Soy and Breast Cancer
Apart from age, and a family history of breast cancer, lots of the known risk factors for breast cancer connect with a woman’s birth history, and any use of oral contraceptives and hormone replacement therapy (HRT). A lot of breast cancers are oestrogen dependant and, more recently, the role of dietary factors and particularly the high consumption of phytoestrogens, which are very weak mimics of natural oestrogens, have been associated with a lower incidence of breast cancer.
Indeed, the incidence of breast cancer in Eastern countries such as Japan is around one-third that of Western countries and one of the major differences in diet between these populations is that the Japanese and the Chinese consume a conventional diet rich in soy products that are recognized to be particularly rich in phytoestrogens. There’re a few types of phytoestrogens and the isoflavones contained in high concentrations in soy products, and also red clover, are the most widely studied. Whilst the weak oestrogenic effects of phytoestrogens have been promoted by herbal medicine as a natural alternative to conventional long-term HRT usage, there have been, for some time, mixed views on their use by breast cancer sufferers or breast cancer survivors.
May really breast cancer survivors eat soy foods?
The majority of breast cancers express oestrogen receptors (ER). The patients with breast cancer can have a mix of oestrogen receptor negative (ER-) and ER+ cells, but, typically, one type of cell predominates and this determines treatment. The growth of ER+ breast cancer cells is stimulated by oestrogen, and by the oestrogen-like properties of soybean isoflavones and its action has therefore provided the basis for concern about soy consumption by the patients with breast cancer.
However the largest part of evidence against soy use in breast cancer patients stems from in vivo studies of chemically induced models of mammary carcinogenesis, or in vitro using transgenic mice. Whilst these studies can supply useful information on the mechanisms by which compounds can affect carcinogenic pathways, care must be taken when interpreting results and relating them to humans. As such, the use of human studies is needed to gain any real insight into the link between soy consumption and the progression of breast cancer.
However, several large epidemiological studies have investigated the role of soy isoflavones on the
risk of breast cancer
with encouraging findings.
The latest of such studies, published in the journal of Cancer Epidemiology and Biomarkers Prevention, used data based on The Women’s Healthy Eating and Living (WHEL) Study and has reported no adverse effects of soy foods on breast cancer prognosis. The WHEL Study was a great phase III medical trial that investigated whether changes in the proportion of dietary fruits, vegetables, fibre, and fat could reduce the recurrence of breast cancer and new primary breast cancer, as well as death from any cause, in early-stage breast cancer survivors between 18 and 70 years old.
3,000 and eighty-eight breast cancer survivors, that were diagnosed between 1991 and 2000 with early-stage breast cancer and taking part in WHEL, were followed for a median of 7.3 years and isoflavone intakes were measured post-diagnosis by using a food frequency questionnaire. Women self-reported new outcome events semi-annually, which were then verified by medical records and/or death certificates. The study reported that as isoflavone intake increased, the risk of death decreased (p = 0.02). Furthermore, women with the highest levels of isoflavone intake (>16.3 mg isoflavones) had a 54% reduction in risk of death.
This is the third epidemiologic study to report no side effects of soy foods on breast cancer prognosis, and the authors go as long as advising that clinicians no longer need to advise against soy consumption for women with a
diagnosis of breast cancer
.
Given that some medical researchers still remain confused and even advise that breast cancer survivors should not consume soy or isoflavone containing supplements, these current findings will be full of hopes to help to clarify the safely of these products for women thinking about their use.
More about
soy and breast cancer
, please visit http://www. breast-cancer-patients. com is a new star of Breast Cancer Rehabilitation Website, it will be to provide comprehensive breast cancer prevention knowledge and the latest breast cancer treatment information.
Cycle day 3 (soy isoflavones)
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